UK AstraZeneca jab's link to blood clots 'vanishingly small', say experts last minute news


PremierLeague-News.Com

- The vaccine is no riskier than pregnancy, pill or long haul flight, an expert of blood clots has said

UK AstraZeneca jab's link to blood clots 'vanishingly small', say experts last minute news


PremierLeague-News.Com

- The vaccine is no riskier than pregnancy, pill or long haul flight, an expert of blood clots has said

UK AstraZeneca jab's link to blood clots 'vanishingly small', say experts last minute news
08 April 2021 - 20:00

PremierLeague-News.Com - Breaking Sport Transfer News ! Having the AstraZeneca jab puts you at no greater risk of blood clots than pregnancy, taking the pill or being a passenger on a long haul flight, experts say. The vaccine's link to blood clots is 'vanishingly small' compared to other everyday health risks, scientists have highlighted. Healthy under-30s in the UK will be given the option of choosing a different vaccine instead of the AstraZeneca jab, it was announced on Wednesday, amid concerns about potential links to an extremely rare type of blood clot in the brain. But University of Reading blood clot expert Professor Simon Clarke told the Mirro r he would not recommend declining the AstraZeneca jab based on the scale of the risk presented so far. “I don’t think it would be a rational decision because the risk of thrombosis is vanishingly small. "Also I’m not quite sure you can even determine yet from the vaccine what the risk is when the sample sizes are so far very small.” Weighing up risk was not simple, he continued: “If you’re comparing it to the risk of somebody choosing to going on a plane, they are decide they are willing to do that and to take the risk to go on holiday or for a work trip. Read More Related Articles Latest coronavirus infection rates for Greater Manchester as cases nearly halved in several boroughs Read More Related Articles A third of Greater Manchester's over-70s have had their second Covid vaccine jab as infections continue to fall "You can make a similar risk analysis when you have a vaccine - nobody is forced to have the vaccine.” Researchers evaluating the jab have not proven the vaccine causes the clots, with European regulators choosing to list it as a 'very rare' potential side effect. The UK's Medicines and Healthcare products Regulatory Agency (MHRA) chief executive Dr June Raine said there was a "reasonably plausible" link between the AstraZeneca jab and the clots. But she stressed these were "extremely rare" and the benefits of the vaccine still outweighed the risks of Covid-19 for the vast majority of people. The family of a solicitor who died after getting the jab also encouraged people to continue getting the AstraZeneca shot. Neil Astles, 59, from Warrington, was given his first dose of the AstraZeneca vaccine on March 17 but died in hospital on Easter Sunday. His sister, Dr Alison Astles, told The Telegraph overnight: "If we all have the vaccine, a few of us might have a blood clot but the evidence is that fewer people will die. "We trust the process, we trust the regulator, and despite what has happened to our family, we don't want people to be scared off. That's the message we want to get across." What are the numbers? The MHRA says up to March 31, across the UK it had received 79 reports of blood clots accompanied by low blood platelet count, all in people who had their first doses, out of around 20million doses given of the AstraZeneca jab in total. Of these 79, a total of 19 people have died, the regulator said, although it has not been established what the cause was in every case. Of the 19 who died, three were under the age of 30. The figures suggest the risk of rare blood clot is the equivalent to four people out of every million who receive the vaccine. The European Medicines Agency (EMA) has also carried out its own in-depth review of 62 cases of Cerebral venous sinus thrombosis (CVST) and 24 cases of splanchnic vein thrombosis, in which 18 people died before adding it as a potential but very rare side effect and recommending the rollout continue. Jab compared to other blood clot risks Being hospitalised for any reason increases your risk of a blood clot, experts say. An estimated 50–60% of cases of VTE - the same kind of blood clot being linked to the jab - are caused by a hospital stay, Thrombosis UK says. And two in every 1,000 women are likely to develop a blood clot during or after pregnancy, according to the organisation. A deep vein thrombosis (DVT) blood clot occurs less than one in every 10,000 long-haul flight journeys for people in good health, Thrombosis UK says.

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. According to the EMA, the risks range from five to 12 cases per 10,000 women who take a combined pill for a year, compared with two cases each year per 10,000 women who are not using that kind of birth control. The Astra Zeneca vaccine (Image: Huddersfield Examiner) Beverley Hunt, professor of thrombosis and haemostasis at King’s College London, who is also a representative of Thrombosis UK told The Guardian : “The combined oral contraceptive pill is probably the commonest cause of cerebral sinus thrombosis, so it is a very good comparison.” Experts have pointed out that the risk of blood clots in pregnancy could be even higher than from taking the pill for some women, depending on their family history and lifestyle factors. According to the Royal College of Obstetricians and Gynaecologists, the risk of venous thrombosis remains uncommon in pregnancy or in the first six weeks after birth, occurring in around one to two per 1,000 women. Risk factors include family history of blood clots, being overweight or a smoker, heart and lung diseases, being over 35, using a wheelchair, or having already had three or more babies. Many concerned women in recent days have posted on social media comparing the blood clot risk to the pill, with some saying they were not screened for clot risks before being given birth control. Prof Clarke said in an ideal situation, health professionals prescribing the pill should be asking women about medical and family history. Prof Clarke added it would be “appalling” if it was being doled out without health risk checks. Read More Related Articles Four more people have died in Greater Manchester hospitals after testing positive for coronavirus Read More Related Articles How to sign up to our newsletter to get the latest headlines from the M.E.N. However one key difference between the vaccine and the pill is that there remains a variety of other contraceptive options. By comparison, the range of vaccines on offer in the UK was at this stage quite limited and studies had not yet established a causal link between the jab and rare blood clots, Prof Clarke added. It remained possible no causal link would be found - but the evidence at the moment appears to be heading in a direction that it was, he said But studies would need to determine what factors - such as medicines, health or lifestyle conditions - could trigger a clot he explained, adding blood clots can also occur due to “random chance”. Authorities were being cautious while they investigated because the risk-benefit analysis was different for younger people less at risk of a severe case of Covid, he added. “They have a tiny risk of blood clot but then they have a tiny risk of severe Covid, as well," Prof Clarke saod. "As someone in my 40s, I’ve got a tiny risk of blood clot but a higher risk of Covid, so in my case the decision about whether to take the risk is clear.” He pointed out that the data pool remained unreliable as the vast majority of young people vaccinated so far in the UK included those being offered jabs early because of their underlying health issues, It was also too early to say if the risk was higher for young women. The UK was vaccinating health and care workers first and that sector had higher proportions of women than men working in it, Prof Clarke said. A broader range of people would need to get the vaccine to get a clearer picture of whether there was a causal link, who exactly was at risk - and why, Prof Clarke said. Adam Finn, professor of paediatrics at the University of Bristol and a member of the Joint Committee on Vaccination and Immunisation, explained to the Guardian that calculating risk was not simple. “We’ve seen data that the annual risk of dying in a car crash if you regularly travel in a car is about 1 in 20,000, with a lifetime risk of about 1 in 240." He added: “We take those risks for granted.”

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